We studied the interactions of local and systemic anti-osteoporotic drugs on bone microstructure in ovariectomized rats.
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OVX rats received systemic vehicle, PTH, or ALN; tibias were injected with HA2 hydrogel, HA2+ZOL, or NaCl, with 8-week in vivo microCT tracking.
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HA2 and HA2-ZOL increased bone mass locally in vehicle rats within 2 weeks, but bone resorption resumed afterward.
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ALN rats showed extended bone gains, while PTH rats showed the greatest benefit from ZOL, indicating a cumulative drug effect.
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The hydrogel effects were localized to the injection site, promoting site-specific bone formation compatible with systemic treatments.
