Combining systemic and local osteoporosis treatments: A longitudinal in vivo microCT study in ovariectomized rats

We studied the interactions of local and systemic anti-osteoporotic drugs on bone microstructure in ovariectomized rats.
  • OVX rats received systemic vehicle, PTH, or ALN; tibias were injected with HA2 hydrogel, HA2+ZOL, or NaCl, with 8-week in vivo microCT tracking.
  • HA2 and HA2-ZOL increased bone mass locally in vehicle rats within 2 weeks, but bone resorption resumed afterward.
  • ALN rats showed extended bone gains, while PTH rats showed the greatest benefit from ZOL, indicating a cumulative drug effect.
  • The hydrogel effects were localized to the injection site, promoting site-specific bone formation compatible with systemic treatments.

Related Posts

Magot removal…

These types of videos have recently become popular on social networks, because they are considered relax

These are the signs that he is… See more

Mouth cancer is a type of cancer of the throat and head and is often treated as such. Mouth cancer mostly occurs after the age of 40,…

78-year-old Susan Sarandon criticized for her clothing – has the perfect response for haters

Susan Sarandon has long been celebrated as one of Hollywood’s most fearless icons. With a career spanning decades, she has proven her talent time and again while…

The Hidden Betrayal: How One Woman Discovered Her Home Was Secretly Transferred

After twenty years of contributing to their shared home, Nikki was devastated to learn that her husband had secretly transferred the house deed to his mother without…

These are the consequences of sleeping with the… See more

Sleeping with the wrong person can have lasting emotional consequences that extend far beyond the physical encounter. What may seem like a moment of pleasure can quickly…

My DIL Abandoned Her Child with Me – 16 Years Later She Showed Up on My Doorstep With an Outrageous Demand

Sixteen years ago, my daughter-in-law (DIL) left her newborn son with me, claiming she needed a short break. That “break” turned into a permanent absence. She never…

Leave a Reply

Your email address will not be published. Required fields are marked *